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骆文静
2010-06-16 18:01   发布范围:公开

    骆文静:女,1968年6月出生,医学博士,教授,博士生导师。第四军医大学军事预防医学系劳动与环境卫生学教研室主任,国家重点学科(军事预防医学)组成学科、国家“211工程”和军队“530工程”重点建设学科带头人。
    1991年7月毕业于天津医科大学营养与食品卫生学专业,获医学学士学位;1996年7月毕业于第四军医大学军队卫生学专业,获医学硕士学位;2002年7月毕业于第四军医大学病理学专业,获医学博士学位;2002年至2004年在第四军医大学军事预防医学专业从事博士后研究;2005年至2006年在美国纽约大学环境医学研究从事博士后研究。
   现任中国环境科学会环境医学与健康分会委员,陕西省环境卫生学专业委员会副主任委员,陕西省学校卫生学专业委员会常委,西安市预防医学会常务理事,全军军队卫生学专业委员会委员。
   长期从事特殊环境有害因素对健康影响及其防护的基础与应用研究,主要研究方向在于生活和作业环境有害因素(锰、铅、环境应激等)对机体的影响、作用机制及防护措施。近五年发表SCI收录论文二十余篇,其中第一及通讯作者15篇;作为主编、副主编、编委,编辑撰写著作5部;主持国家科技支撑计划课题、国家重大新药创制、国家自然科学基金、省部级课题等10余项;两项科研成果获得省部级(军队)科技进步二等奖。培养研究生6名。2006年获总后勤部育才奖银奖,2008年获陕西省青年科技奖和首届西安青年科技奖,并被评为解放军总后科技新星,2009年获教育部“新世纪优秀人才支持计划”资助,荣立三等功一次。

    主要科研论文目录:
1. Luo W, Li J, Zhang D, Song L, Yin XM, Desai D, Amin S, Chen J, Huang C. Bid Mediates Anti-Apoptotic COX-2 Induction through the IKKbeta/NFkappaB Pathway Due to 5-MCDE Exposure.Curr Cancer Drug Targets. 2010 Jan 1. [Epub ahead of print]
2. Du K, Chen Y, Dai Z, Bi Y, Cai T, Hou L, Chai Y, Song Q, Chen S, Luo W*, Chen J. Molecular cloning and functional characterization of a mouse gene upregulated by lipopolysaccharide treatment reveals alternative splicing. Biochem Biophys Res Commu. 2010, 391: 267–271
3. Yang Q, Wang R, Shi B, Zhang W, Ke T, Yang Y, Chen X, Cao B, Liu X, Zhang Y, Ni C, Chen J, Luo W*. Effects of Plateau Environment on Social Interaction. HealthMed. 2010; 4(1):58-62.
4. Zhao F, Cai T, Liu M, Zheng G, Luo W*, Chen J. Manganese induces dopaminergic neurodegeneration via microglial activation in a rat model of manganism. Toxicol Sci. 2009; 107(1):156–164 
5. Liu M, Cai T, Zhao F, Zheng G, Wang Q, Chen Y, Huang C, Luo W*, Chen J. Effect of Microglia Activation on Dopaminergic Neuronal Injury Induced by Manganese, and Its Possible Mechanism. Neurotox Res. 2009, 16(1):42-9
6. Zheng G, Zhang W, Zhang Y, Chen Y, Liu M, Yao T, Yang Y, Zhao F, Li J, Huang C, Luo W*, Chen J. γ-aminobutyric acidA (GABAA) receptor regulates ERK1/2 phosphorylation in rat hippocampus in high doses of Methyl Tert-Butyl Ether (MTBE)-induced impairment of spatial memory. Toxicol and Appl Pharmacol. 2009; 236( 2): 239-245
7. Luo W, Chen Y, Liu M, Du K, Zheng G, Cai T, Zhang W, Zhao F, Yao T, Yang R, Chen J. EB1089 induces Skp2-dependent p27 accumulation, leading to cell growth inhibition and cell cycle G1 phase arrest in human hepatoma cells. Cancer Invest. 2009; 27(1):29-37
8. Luo W, Liu J, Li J, Zhang D, Liu M, Addo JA, Patil S, Zhang L, Yu J, Buolamwini JK, Chen J, Huang C. Anti-cancer Effects of JKA97 are Associated with its Induction of Cell Apoptosis via a Bax-dependent, and p53-independent Pathway. J Biol Chem. 2008, 283(13):8624-33.
9. Ouyang W, Luo W(Co-firster authors), Zhang D, Jian J, Ma Q, Li J, Shi X, Chen J, Gao J, Huang C. PI-3K/Akt Pathway-Dependent Cyclin D1 Expression Is Responsible for Arsenite-Induced Human Keratinocyte Transformation. Environ Health Persp. 2008, 116(1): 1-6.
10. Lu L, Qiu J, Liu S, Luo W*. Vitamin D3 analogue EB1089 inhibits the proliferation of human laryngeal squamous carcinoma cells via p57. Mol Cancer Ther. 2008 May;7(5):1268-74.
11. Zheng G, Chen Y, Zhang X, Cai T, Liu M, Zhao F, Luo W*, Chen J. Acute cold exposure and rewarming enhanced spatial memory and activated the MAPK cascades in the rat brain. Brain Res. 2008;1239:171-180.
12. Cai T, Yao T, Li Y, Chen Y, Du K, Chen J, Luo W*. Proteasome inhibition is associated with manganese-induced oxidative injury in PC12 cells. Brain Res. 2007, 1185: 359-65
13. Zheng G, Zhang X, Chen Y, Zhang Y, Luo W*, Chen J. Evidence for a role of GABAA receptor in the acute restraint stress-induced enhancement of spatial memory. Brain Res. 2007, 1181:61-73.
14. Wang Q, Luo W(Co-firster authors), Zheng W, Liu Y, Xu H, Zheng G, Dai Z, Zhang W, Chen Y, Chen J. Iron supplement prevents lead-induced disruption of the blood-brain barrier during rat development. Toxicol and Appl Pharmacol. 2007, 219(1):33-41.
15. Wang Q, Luo W, Zhang W, Liu M, Song H, Chen J. Involvement of DMT1 +IRE in the transport of lead in an in vitro BBB model. Toxicol in Vitro. 2009,
16. Yang RH, Hu SJ, Wang Y, Zhang WB, Luo WJ, Chen JY. Paradoxical sleep deprivation impairs spatial learning and affects membrane excitability and mitochondrial protein in the hippocampus. Brain Res. 2008;1230:224-32.
17. Du K, Chai Y, Hou L, Chang W, Chen S, Luo W, Cai T, Zhang X, Chen N, Chen Y, Chen J. Over-expression and siRNA of a novel Environmental lipopolysaccharide responding gene on the cell cycle of the human hepatoma derived cell line HepG2. Toxicology, 2008, 243:303-310.
18. Wang Q, Luo W, Zhang W, Dai Z, Chen Y, Chen J. Iron supplementation protects against lead-induced apoptosis through MAPK pathway in weanling rat cortex. NeuroToxicology. 2007, 28(4):850-859. 
19. Liu YL, Bi H, Chi SM, Fan R, Wang YM, Ma XL, Chen YM, Luo WJ, Pei JM, Chen JY. The Effect of Compound Nutrients on Stress-induced Changes in Serum IL-2, IL-6 and TNF-a Levels in Rats. Cytokine. 2007, 37:14-21.
20. Ding J, Wu K, Zhang D, Luo W, Li J, Ouyang W, Song L, Huang C. Activation of both nuclear factor of activated T cells and inhibitor of nuclear factor-kappa B kinase beta-subunit-/nuclear factor-kappa B is critical for cyclooxygenase-2 induction by benzo[a]pyrene in human bronchial epithelial cells.Cancer Sci. 2007; 98(9):1323-9.

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